SOD2 and Insulin resistance: MnSOD is a major antioxidant owing to its localization in the mitochondrial matrix, and it plays a critical role in protecting mitochondria and islets from elevated levels of reactive oxygen species (ROS) (Chen et al. 2005; Fridovich 1995), which may serve as an important trigger of insulin resistance and type 2 diabetes (Anderson et al. 2009; Hoehn et al. 2009; Houstis et al. 2006).