In other hematological cancers, CX3CR1 and its ligand, CX3CL1, have been proposed to be involved in the interaction between chronic lymphocytic leukemia cells and their microenvironment,30 and CCR1 has a crucial role in the pathogenesis of myeloma-associated bone disease. This evidence concerns the gene CCR1 and hematopoietic and lymphoid cell neoplasm.