CD97 is upregulated in a variety of other malignancies, including glioblastoma,42 digestive and thyroid cancers.43GPR56 and GPR114 are specifically overexpressed in FLT3-ITD-mutated samples and GPR126 is most specific to AML with MLL translocations. The gene discussed is ADGRG6; the disease is acute myeloid leukemia.