NPM1 and acute myeloid leukemia: We next studied GPCR expression levels in relation to the most frequent AML genetic subgroups represented in this cohort, that are AML with t(8;21)(q22;q22), inv(16)(p13.1q22) or MLL translocations, and normal karyotype AML with NPM1, DNMT3A or FLT3-ITD mutations (Supplementary Table 2).