In addition, GPR126 expression differed between subtypes of MLL rearranged leukemias according to the translocation partners, being overexpressed at a high level in AML samples with the MLL-MLLT4, MLL-ELL and MLL-SEPT9 fusions and not expressed in the majority of AML samples with the MLL-MLLT3 and MLL-MLLT1 fusions (Supplementary Figure 7). Here, MLLT3 is linked to acute myeloid leukemia.