The significant expression changes on genes like Sox2, Eed and Sp1 were only identified in Cluster I. Since Sox2 highly expresses in stem cells such as pluripotent stem cells and neuron stem cells, we hypothesized this Cluster I EMT as stemness EMT, which will provide new information for understanding the roles that EMT play during cancer progression and generation of iPSCs [6, 11]. This evidence concerns the gene SP1 and cancer.