Activated platelets also promote leukocyte binding of vascular cell adhesion molecule-1 and P-selectin and increase platelet adhesion to atherosclerotic endothelium.24 Circulatory proinflammatory cytokines including C-reactive protein, interleukin-6, and interleukin-1 increase in correlation with activated leukocyte aggregation.25 These phenomena in persons under stress would cause the formation and progression of atherosclerosis and subsequently provoke CAD and CVD development. The gene discussed is VCAM1; the disease is coronary artery disorder.