MUTYH and hereditary cancer: Most notably, defects in repair of one of the most abundant oxidative DNA lesion, 8-oxo-deoxyGuanine (8-oxo-G), are implicated in familial cancer syndromes involving mutations in the DNA glycosylases MutY homolog (MUTYH) or 8-oxoguanine DNA-glycosylase 1 (Ogg1).