The CFH Y402H allele was significantly associated with AMD in both sporadic and familial cases (OR 1.81; 95% CI 1.57–2.09; and OR 2.20; 95% CI 1.58–3.06, respectively (p < 0.001)), and contrary to the ARMS2 SNP, this association did not significantly differ between familial and sporadic patients. This evidence concerns the gene CFH and age-related macular degeneration.