In fact, several studies have shown that patients with COPD, even during stable periods, have higher values of CRP, fibrinogen, interleukin (IL)-6, and tumor necrosis factor (TNF)-α as compared with those in healthy controls, and elevated levels of these markers of inflammation are associated with an increased risk of disease exacerbations and death [4–6,16,17]. This evidence concerns the gene TNF and chronic obstructive pulmonary disease.