Moreover exposure to low protein diet during pregnancy created hypercholesterolaemia in ApoE*3-Leiden mice offspring, which co-existed with development of severe atherosclerotic lesions within the aortic arch and suppressed mRNA expression of LDL receptor-related protein 1 and hepatic sterol regulatory element-binding protein-1c genes [27]. The gene discussed is APOE; the disease is Hypercholesterolemia.