In the present study, based on four public microarray gene expression datasets with case-control study design, we have dug out 10 significant genes (IFI6, IFI27, IFI44L, OAS1, OAS2, EIF2AK2, PLSCR1, STAT1, RNASE2, and GSTO1) which are commonly regulated with SLE in three representative types of blood-born samples. Here, RNASE2 is linked to systemic lupus erythematosus.