Meanwhile, monocyte sample presents a most striking fold change for these three genes, as compared with PBMC and whole blood (8.82–251.66 vs. 3.73–74.05 vs. 1.19–1.87), implying thatmonocyte is a dominant, if not exclusive, cell type actively expressing IFI6, IFI27, and IFI44Lin SLE patients’whole blood.The above observations suggest that monocyte-expressed interferon pathway genes are significantly involved in the pathogenesis of SLE. This evidence concerns the gene IFI27 and systemic lupus erythematosus.