In the present study, based on four public microarray gene expression datasets with case-control study design, we have dug out 10 significant genes (IFI6, IFI27, IFI44L, OAS1, OAS2, EIF2AK2, PLSCR1, STAT1, RNASE2, and GSTO1) which are commonly regulated with SLE in three representative types of blood-born samples. This evidence concerns the gene OAS2 and systemic lupus erythematosus.