We observed three variants that belong to APOA5-APOA4 intergenic region, rs633389 (OR = 0.49; P value = 1.72x10-6), rs1263163 (OR = 0.48; P value = 6.8x10-8) and rs2849165 (OR = = 0.47; P value = 1.6x10-12) to be significantly associated with CAD under log additive model. The gene discussed is APOA5; the disease is coronary artery disorder.