PHF1 and tauopathy: Since the P301S mouse model of tauopathy exhibits several pathological features of human disease, including neurodegeneration (Hampton et al., 2010), loss of synapses (Yoshiyama et al., 2007), defects in synaptic transmission (Yang et al., 2015), loss of dendritic spines and cortical plasticity (Hoffmann et al., 2013), and aberrant neuronal morphology (Mellone et al., 2013), we were also interested to examine whether a reduction in PHF1 levels by TFEB would mitigate markers of neurodegeneration and synapses.