However, the levels of PHF-tau were reduced from 372% in the P301S model of tauopathy to 171% (p < 0.001) when flag-TFEB was overexpressed in the P301S/flag-TFEB double-transgenic mice in the cortex at 7 months of age (Fig. 6A, panel 1, B). Here, TFEB is linked to tauopathy.