SOD1 and amyotrophic lateral sclerosis: Mutations in SOD1 lead to protein misfolding and aggregate formation (Rotunno and Bosco, 2013) and have been shown to induce endoplasmic reticulum (ER) stress and proteasomal dysfunction, which trigger several stress-activated disease processes in ALS (Kikuchi et al., 2006; Kieran et al., 2007).