Constitutive activation of NF-κB in WT microglia induces both gliosis and motoneuron cell death (Frakes et al., 2014), and therefore ablating this activation may ameliorate both of these hallmarks of ALS aetiology, further highlighting a potential neuroprotective role for bid depletion in microglia. Here, NFKB1 is linked to amyotrophic lateral sclerosis.