In a combined cohort of patients enrolled in clinical studies for HIV-associated cryptococcal meningitis in Thailand, Malawi, South Africa, and Uganda, the median baseline CD4 count was just 24 cells/μL (IQR 10–50 cells/μL) [31], with similar CD4 counts observed in Botswana [42], Uganda [43••], and Vietnam [29]. Here, CD4 is linked to Cryptococcal meningitis.