TNC and systemic sclerosis: Finally, a meta-analysis of three distinct transcriptome data sets (GSE56038 and GSE59785) comprising skin biopsies from a total of 80 SSc patients (70 diffuse cutaneous SSc (dcSSc) and 10 limited cutaneous (lcSSc)) and 26 healthy controls confirmed significantly elevated tenascin-C mRNA (P<0.00010, Mann–Whitney U) in the inflammatory gene expression subset biopsies (comprising 36% of all SSc biopsies) compared with healthy control biopsies.