TNC and systemic sclerosis: A replication study with an independent cohort of 27 patients (including 3 with localized scleroderma or morphea) and 6 healthy controls (GSE9285) confirmed elevated tenascin-C expression in the inflammatory intrinsic subset biopsies (comprising 34% of SSc biopsies) compared with healthy control biopsies (P=0.030, Mann–Whitney U)9 (Supplementary Fig. 1B).