It is noteworthy that tenascin-C expression levels in individual SSc skin biopsies showed a positive correlation with TLR4 as well as with IL-6, and in skin fibroblasts tenascin-C elicited TLR4-dependent fibrotic responses, including upregulation of IL-6, and of TLR4 itself. The gene discussed is TLR4; the disease is systemic sclerosis.