BDNF and neuroblastoma: In a previous study, using siRNAs targeted to each individual BDNF transcripts, we demonstrated that siRNAs against either the coding sequence (exon 9) or the isoforms 4, 6, 9a that are located in the second exon cluster were able to decrease the survival of SK-N-BE neuroblastoma cells (a model carrying MYCN amplification) following treatment with cisplatin (Baj and Tongiorgi, 2009).