Alterations in IFN-stimulated gene patterns (including in Ifit, Mx2, Cxcl10) and/or in Jak/STAT activity, a main IFN-dependent pathway, cause a failure in immunological tolerance resulting in T cell-mediated autoimmune pathologies (e.g., type I diabetes) [55]. Here, SOAT1 is linked to type 1 diabetes mellitus.