Focusing on allergy, it seems that cocoa intake could also be beneficial in aspects other than IgE synthesis because, as shown here, it down-regulates the expression of genes, such as Fcer1a, Ms4a2 and Tac4, involved in several GO terms related to mast cell-mediated immunity, its activation and its degranulation, key events in allergic response. This evidence concerns the gene MS4A2 and allergic disease.