Positivity for anti-HCP2 antibodies in patients with RA was found to be associated with radiological evidence of increased damage, as detected by higher Larsen scores after 24 months, with a median (Q1-Q3) score of 10 (4–14) compared with a score of 8 (5–13) in anti-HCP2-negative individuals (p < 0.05). This evidence concerns the gene CYCSP52 and rheumatoid arthritis.