AGBL2 and rheumatoid arthritis: The frequency of anti-CCP2 positivity increased after disease onset and the combinations of anti-CCP2–, anti-VCP1–, anti-VCP2+ and anti-CCP2–, anti-VCP1+, anti-VCP2+ antibodies disappeared when comparing the pre-symptomatic individuals with patients with RA (Fig. 4a–b).