We took advantage to focus on these fully characterized ACPA targets, corresponding to exogenous antigens (i.e., viral citrullinated peptide (VCP)1 derived from EBNA1, VCP2 from EBNA2) or endogenous antigens (histone citrullinated peptide (HCP)1 and HCP2 from histone H4), to analyse a cohort of individuals without joint symptoms who have subsequently developed RA. The gene discussed is CYCSP52; the disease is rheumatoid arthritis.