FLG and rheumatoid arthritis: In this study, we therefore took the opportunity to investigate further the role of citrullinated-histone-4-derived peptides and EBV-derived peptides in the aetiology of RA, by analysing individuals before the onset of symptoms of RA and by comparing the results with those obtained with anti-CCP2 and citrullinated peptides from alpha-enolase, fibrinogenß-chain and filaggrin.