HK2(+)/Beta2AR(+) in HCC samples had poorer prognosis as compared with HK2(−)/Beta2AR(−) in both univariate analysis (HR = 4.69, 95%CI = 2.91–7.57, P < 0.0001) and multivariate analysis (P < 0.0001). This evidence concerns the gene HK2 and hepatocellular carcinoma.