In the non-metastatic sub-group a significant correlation of clustered CD147 positive cells with largest basal diameter (p = 0.039), height (p = 0.047) and TNM-stage (p = 0.013) was evident.<h4>Conclusions</h4>These data may indicate that CD147 regulates MMP-2 expression in uveal melanoma cells. This evidence concerns the gene MMP2 and uveal melanoma.