To explore the effect of AFP on paclitaxel in regulating the proliferation of HCC cells and normal liver cells, Bel 7402 cells were transfected with AFP-siRNA vectors, and HLE or L-02 cells were transfected with pcDNA3.1-afp vectors followed by treatment with paclitaxel (5 μg/ml and 20 μg/ml). The gene discussed is AFP; the disease is hepatocellular carcinoma.