CASP3 and neoplasm: Consecutive sections of tumor tissue were stained for activated caspase-3, as an indicator of apoptosis (Fig. 3b and d); MR mice had significantly elevated levels of activated caspase-3 (MR: 3.82 ± 0.66 % cells, p < 0.05), compared with CF mice (CF: 2.44 ± 0.30 % cells) (Fig. 3f).