The aim of this study was to determine the role of TRPV1 in two distinct models of allergic asthma by adopting two different approaches; incorporating the use of genetically modified TRPV1−/− animals and utilising a selective, potent, clinically ready, small molecule TRPV1 inhibitor [18] to test the hypothesis. The gene discussed is TRPV1; the disease is allergic asthma.