CEACAM5 and neoplasm: Worse DFS was significantly associated with the following factors: male gender (HR = 1.78, p = 0.025), symptomatic disease (HR = 2.21, p = 0.002), moderate and heavy smoker (p = 0.018), preoperative CEA ≥ 5.0 ng/ml (HR = 1.89, p = 0.032), larger maximal tumor size (p < 0.001), not all ADC (HR = 2.08, p = 0.008), advanced pT (p < 0.001), lymph node involvement (p < 0.001) and adjuvant chemotherapy (HR = 2.07, p = 0.004) (see Supplementary Fig. S1).