REN and polycystic ovary syndrome: It has been previously proven that androgens have a stimulatoryaction on renin-angiotensin system (RAS), upregulating the angiotensinogen and reninmRNA expression, increasing angiotensin II and plasma renin activity, and enhancingthe angiotensin type 1 receptor pathways (24, -26).Moreover, high levels of plasma androgens increased the renal cortical expression ofACE in a rat model of PCOS (26).