One of the main therapeutic enzymes of microbial origin, L-asparaginase (L-asparagine amino hydrolase, E.C. 3.5.1.1) is used as a chemotherapeutic agent to treat a number of lymphoproliferative disorders and lymphomas, especially acute lymphoblastic leukemia (ALL) [1,2]. Here, ASPG is linked to acute lymphoblastic leukemia.