Although several genetic factors were reportedly associated in patients with ICAS, such as polymorphisms in adipocytokines, lipoprotein lipase, and C-reactive protein, they were also associated with extracranial atherosclerosis.[14] In addition, recent genome-wide association studies have shown stroke subtype-sensitive genetic factors.[15] However, they merged intracranial and extracranial atherosclerosis for the study. Here, CRP is linked to familial isolated congenital asplenia.