RNF213 and multiminicore myopathy: Several non-p.Arg4810Lys RNF213 variants (rs148731719 and rs397514563) were recently found in Caucasian and East and South Asian cases with MMD.[9,31–33] In addition, clinical manifestations and possibly angiographic findings may differ between Westerners and East Asians.[34] The p.Arg4810Lys RNF213 variant is reportedly related to ischemic-type MMD, whereas non-p.Arg4810Lys RNF213 variants (especially A4399T) are associated with hemorrhagic-type MMD.[31] Further studies on biomarkers in these populations are needed.