A genome-wide linkage analysis and exome analysis recently identified the ring finger protein 213 gene (RNF213) on 17q25.3 as the strongest susceptibility gene for MMD in East Asian people.[8,9] However, this genetic variant associated with MMD was also observed in patients with non-MMD intracranial stenosis.[10,11] [12]. The gene discussed is RNF213; the disease is multiminicore myopathy.