MYD88 and susceptibility to pneumonia measurement: For this, we measured S. pneumoniae induced platelet activation in a variety of assays in human and mouse blood, investigated a possible role for TLR signalling herein, and performed in vivo pneumonia experiments with platelet specific MyD88 depleted (Plt-Myd88-/-) mice to determine the potential role of TLR mediated MyD88 signaling in platelets during S. pneumoniae induced pneumosepsis.