Transient changes in H3 acetylation and H3K4, H3K9 and H3K27 methylation in IL-8 gene promoter were induced by LPS and pretreatment of HT-29 colon cancer cells with deacetylase inhibitors amplified LPS-induction of IL-8 [17]. Here, CXCL8 is linked to colonic neoplasm.