CDK1 and neoplasm: However, given the data suggesting that over-expression of B cyclins in the mouse results in tumor progression26 and the number of papers suggesting that cyclin B is over-expressed in human tumors as compared to normal tissue91, 92, 93, 94, 95, 96, we believe that our data suggesting that the premature activation of cdk1 is a potent way of killing tumor cells, certainly has broad significance for the field of tumor therapeutics (Fig. 7b).