Another mechanism of c-MYC regulation is through FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase), which plays a key role in c-MYC protein degradation in a Thr58-dependent manner,19 and this mechanism has been shown to play a critical role in leukemia-initiating cells.20 The gene discussed is FBXW7; the disease is leukemia.