MYC and Familial prostate cancer: c-MYC mRNA levels are low in quiescent cells but increase within 1–3 h upon mitogen stimulation.13 Forced expression of c-MYC induces cell cycle re-entry of quiescent cells, but the downregulation or inactivation of c-MYC results in the impairment of cell cycle progression.14 Amplification of c-MYC is found in nearly half of human solid tumors,15 including 30% of prostate cancer.14