Apoptotic cell death plays an important role in liver disease, and tumor necrosis factor receptor-1 (TNFR1) and Fas (CD95) are the most prominent cell death receptors involved.1 Both TNF and Fas ligand initiate a signalling pathway leading to apoptosis through receptor Fas-associated death domain (FADD) recruitment and activation of procaspase-8 leading to downstream procaspase-3 activation. The gene discussed is FAS; the disease is liver disorder.