DKC1 and dyskeratosis congenita: In support of these data, it has been shown recently that transient depletion of DKC1 does not affect ribosome composition.47 Therefore, to investigate whether there was a correlation between reduced DKC1 expression and synthesis of translation machinery, three cell lines derived from patients with dyskeratosis congenita that had a mutation in DKC1 gene were used as an alternative.