Interestingly, a reduction in DKC1 RNA levels in CLL B cells has been shown previously, and the data suggested that this correlated with telomeric changes in B-CLL.54 However, our data show that in PB CLL B cells there is a reduction in DKC1 protein expression in a subset of patient samples (Figure 2bi and ii) and no correlation with telomere length was identified (data not shown). The gene discussed is DKC1; the disease is B-cell chronic lymphocytic leukemia.