It was shown using DKC1-mutant cell line that non-pseudouridylated rRNA processing was delayed and resulted in reduced amounts of matured 18S and 28S rRNAs compared with the wild-type cell.46 As such, total levels of matured 18S and 28S rRNAs were markedly reduced in CLL patients compared with control B cells in our study (Figure 4d), thus confirming an aberrant ribosome biogenesis in CLL. This evidence concerns the gene DKC1 and B-cell chronic lymphocytic leukemia.