Interferon alpha-inducible protein 27 (IFI27), which confers EMT, tumorigenicity and stemness,31 stromal interaction molecule 1 (STIM1), which promotes tumor metastasis32 and apoptosis resistance,33 melanoma antigen family B2 (MAGEB2), which activates cell proliferation and resistance to ribotoxic stress,34 and kinase anchor protein 12 (AKAP12), which promotes tumor development and metastasis,35 were all upregulated in Bx-GEM cells but downregulated in Bx-Q and Bx-SF cells compared with parental BxPC-3 cells. This evidence concerns the gene AKAP12 and neoplasm.