TGM2 and neoplasm: In an opposite effect, matrix changes induced by TG2 lead to the inhibition of angiogenesis and tumor growth,171 indicating that endothelial TG2 primarily promotes blood vessel formation via enhanced stabilization and migration of neovascularization; however, a part of extracellular TG2 reduces organized vasculature via the excess stabilization and accumulation of ECM following their crosslinking.