Retinoic acid (RA) induces TG2 expression;54, 55 in acute promyelocytic leukemia treated with RA, TG2 has an important role in the neutrophil–granulocyte differentiation and gene expression of neutrophil's cellular functions in addition to related adhesive, migratory, and phagocytic capacities.56 The transcriptional activation of the TG2 gene, TGM2, is mediated by nuclear factor-kappa B (NF-κB),41 RA receptor (RAR)/retinoid X receptor, liver X receptor/RAR, and Sp1.55 Here, TGM2 is linked to acute promyelocytic leukemia.