Nitric oxide (NO) is also a potent inhibitor by promoting S-nitrosylation on the active site C277.67 The decreased S-nitrosylation of TG2 contributes to age-related increases in vascular stiffness.68 Micro-RNA (miR-19) directly downregulates TG2 expression and enhances the invasion of colorectal cancer cells.18 Finally, the SUMOylation of TG2 enhances its protein levels and activity by blocking the ubiquitination of (and thus stabilizing) TG2 protein.69 The gene discussed is TGM2; the disease is colorectal cancer.