SP1 and Hepatic fibrosis: 12 The TG2-induced decrease in c-Met may be involved in the impaired hepatocyte regeneration observed in patients with alcoholic liver diseases.13, 134, 135 Furthermore, Giebeler et al.136 reported that the downregulation of c-Met is associated with liver fibrosis, indicating a novel apoptotic axis accompanied by liver fibrosis, namely, a nuclear TG2/crosslinked Sp1/decline in c-Met.