The main findings reported in this study are (i) that a well-characterized plant extract causes immunogenic cell death in melanoma tumor cells in vitro and (ii) that the induced anti-tumor immunity in vivo, either through vaccination with dying tumor cells or as a result of direct treatment with the extract, mediates significant disease control associated with a detectable tumor-specific CD8 T-cell response. The gene discussed is CD8A; the disease is neoplasm.