CASP6 and early-onset autosomal dominant Alzheimer disease: Since this atypical caspase has been implicated in neurological diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, caspase-6-mediated mTORC1 regulation may be relevant in these age-related diseases.13 Active caspase-6 has been correlated with Alzheimer's disease progression, due to its role in the cleavage of cytoskeletal proteins like α-tubulin, α-actinin-4 and spinophilin, which impairs the cytoskeleton network of neurons.