Different elements, can explain these inconsistencies: differences in mice strains used (BALB/C versus C57Bl/6), different experimental murine models (e.g. caecal ligation and puncture (CLP)- model versus a intranasal inhalation model for sepsis), differences in TREM-2 blockade (e.g. by using TREM-2 deficient mice or TREM-2 antibodies) and lastly the difference of an in vitro approach in contrast to our ex vivo cellular challenge model. Here, TREM2 is linked to Sepsis.