Taking this into account, testing positive for aβ2GPI of any of the three isotypes increased the probability of having APS by a factor of >13, followed by IgM aCL (LR 11.9), IgG aDI (LR 10.0) and IgA aDI (LR 9.5) (Table 3). The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.