Given that both IgA aPL and IgG aDI are considered attractive candidates for new diagnostic tests in APS we designed this study to assess and compare the strength of association of circulating ‘classical’ IgG and IgM aCL and aβ2GPI, IgA aCL and aβ2GPI, and IgG, IgM and IgA aDI with APS and APS-related clinical manifestations. Here, CD79A is linked to autoimmune polyendocrinopathy.