No significant associations were seen for IgM or IgA serological profiles, except that the addition of IgA aDI positivity tripled the HR for thrombosis and converted it from non-significant (HR for thrombosis in aCL/aβ2GPI+(aDI-) subjects 1.1, 95%CI 0.4–2.9) to significant (HR for thrombosis in aCL/aβ2GPI+(aDI+) subjects 3.6, 95%CI 1.4–9.1). This evidence concerns the gene CD40LG and Venous thrombosis.