For both (a) and (b), positivity in each of the nine assays showed a significantly positive HR for APS, with one exception—IgA aCL in the 145 patients with SLE, reflecting the similar prevalence of IgA aCL in both our APS and SLE/no APS patients (38% and 30% respectively, Table 2). The gene discussed is ACLY; the disease is systemic lupus erythematosus.