Our data suggest that measurement of IgA aβ2GPI and aDI would be more valuable than measuring IgA aCL in patients with suspected APS, and we also note that IgA aβ2GPI are more commonly positive in our APS cohort compared to IgM aβ2GPI (Table 2). The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.