Moreover our findings are in accordance with Zhou et al. study in which propranolol decreased inflammatory cell and cytokines (tumor necrosis factor-α and interleukin-8) levels in alveolar fluid of rat.16 In addition decrease of proinflammatory cytokines such as IL-1β and TNF-α in an experimental model of periodontal disease by propranolol have been shown.21 Besides pretreatment with propranolol reversed increase of IL-6 and TNF-α in a mice model. Here, TNF is linked to periodontal disorder.