BRCA1 and ovarian cancer: A recent population series of 2,222 ovarian cancer cases and 1,528 controls characterised the spectrum of mutations further: 85 BRCA1 mutations were detected, comprising 51 frameshift indels and 34 missense, nonsense or splice site mutations; there were also 98 BRCA2 mutations, made up of 75 frameshift indels and 23 missense, nonsense or splice site mutations [17].