Since ADEM and AHLE are frequently preceded by infections, Yildiz et al. commented that the cross-reactivity between human myelin antigens and viral or bacterial antigens likely induce an excessive immunological response and mentioned an AHLE murine model determined by a strong activation of CD8+ T cells in C57BL/6 mice leading to hemorrhagic demyelination within 24 h following injecting of the VP2121–130 viral capsid peptide of the Theiler’s murine encephalomyelitis virus (1). This evidence concerns the gene CD8A and infection.