When comparing between patients having ovarian tumors and control group, we found that ICAM-1 rs1437 CC, CT, and TT genotypes were expressed in 26.7, 46.7, and 26.7% of ovarian tumors patients, respectively, while for healthy volunteers; CC, CT, and TT genotypes were expressed in 0, 40, and 60% of healthy volunteers, respectively, There was statistically significant association between ICAM-1 rs1437 CC and CT genotypes and ovarian cancer, as they have 25- and 2.6-folds, respectively, more odds to be ovarian cancer cases compared to TT allele. The gene discussed is ICAM1; the disease is ovarian neoplasm.