To further understand the impact of Tlr2 polymorphism on autoimmunity and inflammation, we compared global gene usage of enriched LN-derived T cells from F1 (SJL × B6Tlr2−) mice displaying only Tlr282ile of SJL origin, and F1 (SJL × B6wt) having Tlr2 of both SJL (Tlr282ile) and B6 (Tlr282met) strains, with Tlr282met dominant. This evidence concerns the gene TLR2 and Autoimmunity.