We also found a more than 20-fold up-regulation of ISG12-1 mRNA at 1 day post infection (d.p.i.)and a twofold up-regulation of ZC3HAV1 mRNA at 4 d.p.i. However, there were no statistical differences in ISG12-1 and ZC3HAV1 mRNA expression levels in the tumorigenesis phase. The gene discussed is ZC3HAV1; the disease is infection.