Avian leukosis virus subgroup J infection in the early stages resulted in a more than 20-fold up-regulation of ISG121 mRNA at 1 d.p.i. (p < 0.05) and greater than twofold up-regulation of ZC3HAV1 mRNA at 4 d.p.i. (p < 0.05). This evidence concerns the gene ZC3HAV1 and infection.