Binding of anti-PSMA mAbs to non-prostate tissue, as the liver, duodenal epithelial (brush border) cells and proximal tubule cells in the kidney, has been observed, as well as binding to tumor-associated neovasculature in other solid malignancies, including clear cell renal carcinoma, colon and breast carcinoma (Chang, 2004). This evidence concerns the gene FOLH1 and neoplasm.