Thakkinstian et al. (2012) pooled data from 19 studies which happened between 2006 and 2011 for 4 SNPs: rs9332739 and rs547154 for C2 gene and rs4151667 and rs641153 for CFB gene and suggested the robust estimate that these alleles contributed to lowering the risk in all AMD pathogenesis in Caucasian population by 2.0% to 6.0%. The gene discussed is CFB; the disease is age-related macular degeneration.