Recently, it has also been discovered by INDEYE study that polymorphisms in ARMS2/HTRA1 locus are significantly associated with early and late AMD but instead of this locus the complement factors components like C2, CFH and complement factor B (CFB) have not shown positive correlation with AMD pathology (Sundaresan et al., 2012). The gene discussed is CFB; the disease is age-related macular degeneration.