Using targeted amplicon sequencing of ZBTB7A and 45 leukaemia relevant genes, we screened 56 diagnostic AML t(8;21) samples, including one of the two samples analysed by exome sequencing (UPN 1), whereas for the other one (UPN 2) availability of material was insufficient. The gene discussed is ZBTB7A; the disease is acute myeloid leukemia.