MTDH and glioblastoma: The results of the present study have designed DYT-40, a novel synthetic (E)-2-(2-(4-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl) acetate, which significantly blocks malignant glioblastoma growth and invasion via the inhibition of AEG-1 expression.