Furthermore, PI3K (p110) and PI3K (p85) was down-regulated and the tumor gene C-myc was down-regulated after treatment with DYT-40, suggesting that DYT-40 inhibited AEG-1 expression, which is involved in the suppression of the phosphorylation of PI3K/AKT and the MAPK axis. This evidence concerns the gene AKT1 and neoplasm.