MTDH and malignant glioma: Previous studies have shown that AEG-1 is an important positive regulator of nuclear factor kappa-B p65 (NF-κB) and that the activation of NF-κB p65, which is induced by AEG-1, exhibits a key molecular mechanism in which AEG-1 promotes cell growth and invasion in malignant glioma cells8, 21.