CD8A and infection: The proportion (P = 0.04) and number (P = 0.016) of IFN-γ-producing CNS CD8+ T cells in response to the major VP2121-130 capsid epitope at 8 dpi were also significantly lower in the P2/P3-Tg B6 mice compared with their littermates, although the T cell responses became similar 21 days post-infection (Fig. 4a, b).